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We are proud to introduce version 2 of CAMPARI. This version adds many algorithms and features developed and used in recent published work. We would like to highlight in particular the extensions to the data analysis facility (clustering and network-based analysis) and the availability of unusual restraint potentials (e.g., to secondary structure content, spatial density maps, or polymeric descriptors). It continues to support the ABSINTH force field paradigm and implicit solvation model.